Nanorobotics Drug Delivery System and Lab-On-Chip Platform

Nanorobotics

Magnetically guided nanorobots that deliver drugs precisely for cancer treatment and nerve repair, while also enabling fast pathogen detection through a Lab-on-Chip system.
Vector (2)-da6325
Institute:
IIT Delhi
Vector (3)-42d8ac
PI Name:
Prof. Soutik Betal

Technology Readiness Level (TRL)
4

Problem
Addressed

  • Developed a remotely controlled targeted treatment method of cancer using magnetoelectric nanorobots without harmful side-effects.
  • Developed Lab-On-A-Chip platform for swift pathogen detection.
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About the
Technology

  • Remotely controlled targeted treatment of cancer using magnetoelectric nanorobots.
  • Propelling and guiding the nanorobots to targeted cells while dynamically avoiding untargeted cells via electrostatic repulsion
  • Cell-specific targeted permeation by opening nanopore on the phospholipid bilayer membrane of a single targeted cell using the localized electric field generated by the nanorobots, a process known as electroporation.
  • Dynamically attaching nanorobots to the cell membrane of targeted cells via electrostatic bonding and transporting these cells to desired locations in a microvascular environment with microscale accuracy
  • Dynamic sensing of minute electric field differences and membrane properties while moving trajectory among different cell types (both healthy and cancerous cells).

Application Areas & Use Cases

  • Remotely controlled targeted cell permeation by Nanorobots provides phenomenal advancement in targeted drug delivery, safe cell electroporation. Based on type of targeted cell, pores can be electrostatically opened for permeation of cell type.
  • Most importantly, the remotely guided localized treatment of cancer by nanorobots in microvascular environment avoids harmful side effects of the existing chemotherapy treatment method
  • Avoiding untargeted cell toxicity and localized drug exposure in Oncotherapy
  • Remotely controlled targeted cell transport by Nanorobots to microfluidic and precise Lab-ona-chip platform with tunable lab adjustments to detect pathogens in microvascular environments with immunological reagents and Pathogen– Specific Antibodies, which is exceptionally important for actual clinical use